Acetyl-Histone H3 (K14) Polyclonal Antibody, 100ug, (ATB-K0007)

$299.00

Description

Background:

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008]

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Product datasheet:

Overview

Product Description   Acetyl-Histone H3 (K14) Polyclonal Antibody, 100ug, (ATB-K0007)
Image
Species Reactivities Human,Mouse,Rat
Immunogen Synthesized peptide derived from human Histone H3 around the acetylation site of K14.

Properties

Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions -20°C/1 year
Isotype IGg

References:

  1. Breaking the HAC Barrier: histone H3K9 acetyl/methyl balance regulates CENP-A assembly. Ohzeki J, et al. EMBO J, 2012 May 16. PMID 22473132 Free PMC Article
  2. Plant homeodomain (PHD) fingers of CHD4 are histone H3-binding modules with preference for unmodified H3K4 and methylated H3K9. Mansfield RE, et al. J Biol Chem, 2011 Apr 1. PMID 21278251 Free PMC Article
  3. A chemical method for labeling lysine methyltransferase substrates. Binda O, et al. Chembiochem, 2011 Jan 24. PMID 21243721 Free PMC Article
  4. Crystal structure of the human histone methyltransferase ASH1L catalytic domain and its implications for the regulatory mechanism. An S, et al. J Biol Chem, 2011 Mar 11. PMID 21239497 Free PMC Article
  5. Functional impact of cancer-associated mutations in the tumor suppressor protein ING4. Moreno A, et al. Carcinogenesis, 2010 Nov. PMID 20705953
  6. The primary structure and expression of four cloned human histone genes.
    Zhong R., Roeder R.G., Heintz N.
    Nucleic Acids Res. 11:7409-7425(1983) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (HIST1H3B).
  7. Enhancer-facilitated expression of prokaryotic and eukaryotic genes using human histone gene 5′ regulatory sequences.
    Marashi F., Helms S., Shiels A., Silverstein S., Greenspan D.S., Stein G., Stein J.
    Biochem. Cell Biol. 64:277-289(1986) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  8. Isolation and characterization of two human H1 histone genes within clusters of core histone genes.
    Albig W., Kardalinou E., Drabent B., Zimmer A., Doenecke D.
    Genomics 10:940-948(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (H3FD).
  9. Association of a human H1 histone gene with an H2A pseudogene and genes encoding H2B.1 and H3.1 histones.
    Kardalinou E., Eick S., Albig W., Doenecke D.
    J. Cell. Biochem. 52:375-383(1993) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  10. Expression of human histone h1.1 and the nearby core histones.
    Runge D., Eick S., Doenecke D.
    Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Blood.

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