Acetyl-E2F-4 (K96) Polyclonal Antibody, 100ug, (ATB-K0080)

$299.00

Description

Background:

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008]

Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5′-TTTC[CG]CGC-3′ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.

Product datasheet:

Overview

Product Description   Acetyl-E2F-4 (K96) Polyclonal Antibody, 100ug, (ATB-K0080)
Species Reactivities Human, Mouse, Rat
Immunogen Synthesized peptide derived from the human E2F-4 around the acetylation site of K96.

Properties

Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions -20°C/1 year
Isotype IGg

References:

  1. Functional impact of colorectal cancer-associated mutations in the transcription factor E2F4. Paquin MC, et al. Int J Oncol, 2013 Dec. PMID 24100580
  2. E2F4 plays a key role in Burkitt lymphoma tumorigenesis. Molina-Privado I, et al. Leukemia, 2012 Oct. PMID 22475873
  3. E2F4 expression is required for cell cycle progression of normal intestinal crypt cells and colorectal cancer cells. Garneau H, et al. J Cell Physiol, 2009 Nov. PMID 19562678
  4. Nuclear expression of E2F4 induces cell death via multiple pathways in normal human intestinal epithelial crypt cells but not in colon cancer cells. Garneau H, et al. Am J Physiol Gastrointest Liver Physiol, 2007 Oct. PMID 17656449
  5. E2F4 function in G2: maintaining G2-arrest to prevent mitotic entry with damaged DNA. Plesca D, et al. Cell Cycle, 2007 May 15. PMID 17507799 Free PMC Article
  6. E2F-4, a new member of the E2F transcription factor family, interacts with p107.
    Ginsberg D., Vairo G., Chittenden T., Xiao Z.-X., Xu G., Wydner K.L., Decaprio J.A., Lawrence J.B., Livingston D.M.
    Genes Dev. 8:2665-2679(1994) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-319 INS, INTERACTION WITH RBL1, FUNCTION. Tissue: Cervix carcinoma.
  7. E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.
    Beijersbergen R.L., Kerkhoven R.M., Zhu L., Carlee L., Voorhoeve P.M., Bernards R.
    Genes Dev. 8:2680-2690(1994) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH RBL1, FUNCTION. Tissue: Colon carcinoma.
  8. E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle.
    Sardet C., Vidal M., Cobrinik D., Geng Y., Onufryk C., Chen A., Weinberg R.A.
    Proc. Natl. Acad. Sci. U.S.A. 92:2403-2407(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  9. Genomic structure and mutation screening of the E2F4 gene in human tumors.
    Schwemmle S., Pfeifer G.P.
    3.0.CO;2-X”>Int. J. Cancer 86:672-677(2000) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  10. Human protein factory for converting the transcriptome into an in vitro-expressed proteome.
    Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B.
    , Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S., Nomura N.
    Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC]

    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

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