c-Jun (Phospho-Tyr170) Rabbit Polyclonal Antibody, 100 ug

Background: This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008] Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Product datasheet: Overview Product Description Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Tested Applications WB Image Western blot analysis of extracts from Hela and 293 cells untreated or treated with EGF using c-Jun (Phospho-Tyr170) Antibody #11023. Species Reactivities Human Mouse Rat Immunogen Peptide sequence around phosphorylation site of tyrosine 170 (P-V-Y(p)-A-N) derived from Human c-Jun. Properties Storage Instructions Store at -20C Clonality Polyclonal Antibody References: AP-1 Transcription Factor Serves as a Molecular Switch between Chlamydia pneumoniae Replication and Persistence. Krmer S, et al. Infect Immun, 2015 Jul. PMID 25895972 Free PMC Article RNAi-mediated knockdown of the c-jun gene sensitizes radioresistant human nasopharyngeal carcinoma cell line CNE-2R to radiation. Guo SY, et al. Oncol Rep, 2015 Mar. PMID 25571870 Genome-wide profiling of AP-1-regulated transcription provides insights into the invasiveness of triple-negative breast cancer. Zhao C, et al. Cancer Res, 2014 Jul 15. PMID 24830720 Differentiation-associated genes regulated by c-Jun and decreased in the progression of esophageal squamous cell carcinoma. Luo A, et al. PLoS One, 2014. PMID 24796531 Free PMC Article Resveratrol stimulates AP-1-regulated gene transcription. Thiel G, et al. Mol Nutr Food Res, 2014 Jul. PMID 24753227 Structure and chromosomal localization of the functional intronless human JUN protooncogene. Hattori K., Angel P., le Beau M.M., Karin M. Proc. Natl. Acad. Sci. U.S.A. 85:9148-9152(1988) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1. Bohmann D., Bos T.J., Admon A., Nishimura T., Vogt P.K., Tjian R. Science 238:1386-1392(1987) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE. Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201). Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Cloning of human full-length CDSs in BD Creator(TM) system donor vector. Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. NIEHS SNPs program Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].