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VASP Polyclonal Antibody, 100μg, (ATB-T4856)

VASP Polyclonal Antibody, 100μg, (ATB-T4856)

Store / Antibodies and Immunodetection Reagents / Primary Antibodies
$199.00
In stock
Product Details

Background: Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description VASP Polyclonal Antibody, 100μg, (ATB-T4856) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human VASP around the non-phosphorylation site of S157. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Reconstitution of actin-based motility by vasodilator-stimulated phosphoprotein (VASP) depends on the recruitment of F-actin seeds from the solution produced by cofilin. Siton O, et al. J Biol Chem, 2014 Nov 7. PMID 25246528 Role of serum vaspin in progression of type 2 diabetes: a 2-year cohort study. Jian W, et al. PLoS One, 2014. PMID 24732788 Free PMC Article Matrine inhibits the adhesion and migration of BCG823 gastric cancer cells by affecting the structure and function of the vasodilator-stimulated phosphoprotein (VASP). Zhang JW, et al. Acta Pharmacol Sin, 2013 Aug. PMID 23685951 Free PMC Article Natriuretic peptides induce weak VASP phosphorylation at Serine 239 in platelets. Borgognone A, et al. Platelets, 2014. PMID 23469931 Free PMC Article High on-treatment platelet reactivity assessed by various platelet function tests: is the consensus-defined cut-off of VASP-P platelet reactivity index too low? Jeong YH, et al. J Thromb Haemost, 2012 Mar. PMID 22212857

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VASP Polyclonal Antibody, 100μg, (ATB-T4856)
Store / Antibodies and Immunodetection Reagents / Primary Antibodies
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