Tyrosine Hydroxylase (Phospho-Ser31) Rabbit Polyclonal Antibody, 100 ug

Background: The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008] Plays an important role in the physiology of adrenergic neurons. Product datasheet: Overview Product Description Plays an important role in the physiology of adrenergic neurons. Tested Applications WB Image Western blot analysis of extracts from 293 cells treated with Doxorubicin using Tyrosine Hydroxylase (Phospho-Ser31) Antibody #11211. Species Reactivities Human Mouse Rat Immunogen Peptide sequence around phosphorylation site of serine31(V-T-S(p)-P-R) derived from human Tyrosine Hydroxylase Properties Storage Instructions Store at -20C Clonality Polyclonal Antibody References: Brain catecholamine depletion and motor impairment in a Th knock-in mouse with type B tyrosine hydroxylase deficiency. Korner G, et al. Brain, 2015 Oct. PMID 26276013 A new knock-in mouse model of l-DOPA-responsive dystonia. Rose SJ, et al. Brain, 2015 Oct. PMID 26220941 The hTH-GFP reporter rat model for the study of Parkinson's disease. Iacovitti L, et al. PLoS One, 2014. PMID 25462571 Free PMC Article Functional polymorphism (C-824T) of the tyrosine hydroxylase gene affects IQ in schizophrenia. Horiguchi M, et al. Psychiatry Clin Neurosci, 2014 Jun. PMID 24417771 Catalytic domain surface residues mediating catecholamine inhibition in tyrosine hydroxylase. Briggs GD, et al. J Biochem, 2014 Mar. PMID 24334288 Isolation of a novel cDNA clone for human tyrosine hydroxylase: alternative RNA splicing produces four kinds of mRNA from a single gene. Kaneda N., Kobayashi K., Ichinose H., Kishi F., Nakazawa A., Kurosawa Y., Fujita K., Nagatsu T. Biochem. Biophys. Res. Commun. 146:971-975(1987) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). A single human gene encoding multiple tyrosine hydroxylases with different predicted functional characteristics. Grima B., Lamouroux A., Boni C., Julien J.-F., Javoy-Agid F., Mallet J. Nature 326:707-711(1987) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING. Isolation of a full-length cDNA clone encoding human tyrosine hydroxylase type 3. Kobayashi K., Kaneda N., Ichinose H., Kishi F., Nakazawa A., Kurosawa Y., Fujita K., Nagatsu T. Nucleic Acids Res. 15:6733-6733(1987) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Structure of the human tyrosine hydroxylase gene: alternative splicing from a single gene accounts for generation of four mRNA types. Kobayashi K., Kaneda N., Ichinose H., Kishi F., Nakazawa A., Kurosawa Y., Fujita K., Nagatsu T. J. Biochem. 103:907-912(1988) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING. Characterisation of novel splicing variants of the tyrosine hydroxylase C-terminal domain in human neuroblastic tumours. Roma J., Saus E., Cuadros M., Reventos J., Sanchez de Toledo J., Gallego S. Biol. Chem. 388:419-426(2007) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5 AND 6), ALTERNATIVE SPLICING.