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TGIF Polyclonal Antibody, 100μg, (ATB-T4635)

$199.00
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Background: The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013]Product datasheet: Overview Product Description TGIF Polyclonal Antibody, 100μg, (ATB-T4635) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the C-terminal region of human TGIF. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: TGIF1 is a potential candidate gene for high myopia in ethnic Kashmiri population. Ahmed I, et al. Curr Eye Res, 2014 Mar. PMID 24215395 TGIF1 splicing variant 8 is overexpressed in oral squamous cell carcinoma and is related to pathologic and clinical behavior. Libório TN, et al. Oral Surg Oral Med Oral Pathol Oral Radiol, 2013 Nov. PMID 24119525 Homeobox gene transforming growth factor β-induced factor-1 (TGIF-1) is a regulator of villous trophoblast differentiation and its expression is increased in human idiopathic fetal growth restriction. Pathirage NA, et al. Mol Hum Reprod, 2013 Oct. PMID 23761267 Overcoming transcription activator-like effector (TALE) DNA binding domain sensitivity to cytosine methylation. Valton J, et al. J Biol Chem, 2012 Nov 9. PMID 23019344 Free PMC Article Overexpression of TG-interacting factor is associated with worse prognosis in upper urinary tract urothelial carcinoma. Yeh BW, et al. Am J Pathol, 2012 Sep. PMID 22771156

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TGIF Polyclonal Antibody, 100μg, (ATB-T4635)
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