STAT5A/B (Phospho-Ser725/730) Rabbit Polyclonal Antibody, 100 ug

Background: Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.Product datasheet: Overview Product Description Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription. Tested Applications WB Image Western blot analysis of extracts from Jurkat cells treated with EGF using Phospho-STAT5A/B (Ser725/730) antibody #11977.The lane on the right is treated with the antigen-specific peptide. Species Reactivities Human Immunogen Peptide sequence around phosphorylation site of serine725/730(A-P-S(p)-P-V) derived from Human STAT5A/B . Properties Storage Instructions Store at -20°C Clonality Polyclonal Antibody References: STAT5 Orchestrates Local Epigenetic Changes for Chromatin Accessibility and Rearrangements by Direct Binding to the TCRγ Locus. Wagatsuma K, et al. J Immunol, 2015 Aug 15. PMID 26195811 A novel IL-25 signaling pathway through STAT5. Wu L, et al. J Immunol, 2015 May 1. PMID 25821217 Activated STAT5 confers resistance to intestinal injury by increasing intestinal stem cell proliferation and regeneration. Gilbert S, et al. Stem Cell Reports, 2015 Feb 10. PMID 25579133 Free PMC Article Stat5 gene dosage in T cells modulates CD8+ T-cell homeostasis and attenuates contact hypersensitivity response in mice. Nivarthi H, et al. Allergy, 2015 Jan. PMID 25333229 Mammary-specific gene activation is defined by progressive recruitment of STAT5 during pregnancy and the establishment of H3K4me3 marks. Kang K, et al. Mol Cell Biol, 2014 Feb. PMID 24277936 Free PMC Article Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. Mui A.L.-F., Wakao H., O'Farrell A.-M., Harada N., Miyajima A.EMBO J. 14:1166-1175(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6 X A/J. Tissue: Liver. Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue. Liu X., Robinson G.W., Gouilleux F., Groner B., Hennighausen L.Proc. Natl. Acad. Sci. U.S.A. 92:8831-8835(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6J. Zhou L.X., Moore R.C., Oka T.Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C3H/HeN. Tissue: Mammary gland. Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocortiocoid receptor in mammary cells. Cella N., Groner B., Hynes N.E.Mol. Cell. Biol. 18:1783-1792(1998) [PubMed] [Europe PMC] Cited for: INTERACTION WITH NR3C1. ErbB4 signaling in the mammary gland is required for lobuloalveolar development and Stat5 activation during lactation. Jones F.E., Welte T., Fu X.Y., Stern D.F.J. Cell Biol. 147:77-88(1999) [PubMed] [Europe PMC] Cited for: FUNCTION, INTERACTION WITH ERBB4.