Background: The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description SR-5A Polyclonal Antibody, 100μg, (ATB-T4406) Image Species Reactivities Human Immunogen Synthesized peptide derived from the Internal region of human SR-5A. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Serotonin (5-HT) receptor 5A sequence variants affect human plasma triglyceride levels. Zhang Y, et al. Physiol Genomics, 2010 Jul 7. PMID 20388841 Free PMC Article Identification and functional significance of N-glycosylation of the 5-ht5A receptor. Dutton AC, et al. Neurochem Int, 2008 Feb. PMID 17881091 5-ht5A receptors as a therapeutic target. Thomas DR. Pharmacol Ther, 2006 Sep. PMID 16516972 Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. Dietz BM, et al. Brain Res Mol Brain Res, 2005 Aug 18. PMID 15921820 Binding of tetrahydrocarboline derivatives at human 5-HT5A receptors. Khorana N, et al. J Med Chem, 2003 Aug 28. PMID 12930153
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