Phospho-NUDC (S326) Polyclonal Antibody, 100µg, (ATB-P0826)

Background: This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. [provided by RefSeq, Feb 2012]Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.Product datasheet: Overview Product Description Phospho-NUDC (S326) Polyclonal Antibody, 100µg, (ATB-P0826) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human NUDC around the phosphorylation site of S326. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: NudC deacetylation regulates mitotic progression. Chuang C, et al. PLoS One, 2013. PMID 24069238 Free PMC Article [Expression and clinical significance of human nuclear distribution C in nasopharyngeal carcinoma]. Chen Y, et al. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2011 Jan. PMID 21473139 Inhibition of prostate tumor growth by overexpression of NudC, a microtubule motor-associated protein. Lin SH, et al. Oncogene, 2004 Apr 1. PMID 14676831 A homolog of the fungal nuclear migration gene nudC is involved in normal and malignant human hematopoiesis. Miller BA, et al. Exp Hematol, 1999 Apr. PMID 10210332 Interference RNA (RNAi)-based silencing of endogenous thrombopoietin receptor (Mpl) in Dami cells resulted in decreased hNUDC-mediated megakaryocyte proliferation and differentiation. Pang SF, et al. Exp Cell Res, 2009 Dec 10. PMID 19560457 A homolog of the fungal nuclear migration gene nudC is involved in normal and malignant human hematopoiesis. Miller B.A., Zhang M.-Y., Gocke C.D., De Souza C., Osmani A.H., Lynch C., Davies J., Bell L., Osmani S.A.Exp. Hematol. 27:742-750(1999) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Heart. Molecular cloning and characterization of the human NUDC gene. Matsumoto N., Ledbetter D.H.Hum. Genet. 104:498-504(1999) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Human MNUDC protein gene. Song H., Peng Y., Dai M., Huang Q., Mao Y., Zhang Q., Mao M., Fu G., Luo M., Chen J., Hu R.Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pituitary. Unique genes expressed in fibroblasts of periodontal ligament. Yamamoto T., Takashiba S., Myokai F., Washio N., Nishimura F., Arai H., Murayama Y.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Periodontal ligament. Cloning and characterization of a novel human cDNA homology to murine SIG-92 mRNA. Li N.G., Yu L., Tu Q., Fu Q., Wang X.K., Zhao S.Y.Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA].