PPP1R2 (Phospho-Ser120/Ser121) Rabbit Polyclonal Antibody, 100 ug

Background: Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]Inhibitor of protein-phosphatase 1.Product datasheet: Overview Product Description Inhibitor of protein-phosphatase 1. Tested Applications IHC Species Reactivities Human Mouse Rat Immunogen Peptide sequence around phosphorylation site of serine 120 and serine 121 (Q-E-S(p)-S(p)-GE) derived from Human PPP1R2. Properties Storage Instructions Store at -20°C Clonality Polyclonal Antibody References: Phosphatase inhibitor 2 promotes acetylation of tubulin in the primary cilium of human retinal epithelial cells. Wang W, et al. BMC Cell Biol, 2008 Nov 26. PMID 19036150 Free PMC Article Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy. Yamada M, et al. FASEB J, 2006 Jun. PMID 16627625 Phosphorylation of phosphatase inhibitor-2 at centrosomes during mitosis. Leach C, et al. J Biol Chem, 2003 Jul 11. PMID 12697755 Multisite phosphorylation and the nuclear localization of phosphatase inhibitor 2-green fluorescent protein fusion protein during S phase of the cell growth cycle. Kakinoki Y, et al. J Biol Chem, 1997 Dec 19. PMID 9405437 Genetic analysis of human type 1 protein phosphatase inhibitor 2 in insulin-resistant Pima Indians. Permana PA, et al. Genomics, 1997 Apr 1. PMID 9126490 Cloning and characterization of human phosphatase inhibitor-2 (IPP-2) sequences. Sanseau P., Jackson A., Alderton R.P., Beck S., Senger G., Sheer D., Kelly A., Trowsdale J.Mamm. Genome 5:490-496(1994) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli. Helps N.R., Street A.J., Elledge S.J., Cohen P.T.W.FEBS Lett. 340:93-98(1994) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Genetic analysis of human type 1 protein phosphatase inhibitor 2 in insulin-resistant Pima Indians. Permana P.A., Mott D.M.Genomics 41:110-114(1997) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Inhibitor 2 of protein phosphatase 1 is differentially expressed between the colon cancer cell lines SW480 and SW620. Croke D.T., McWilliam P.M., Parle-McDermott A., Dunican D., Tighe O.Submitted (APR-1999) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA]. Cloning of inhibitor-2 of protein phosphatase type 1 from human heart. Mishra S., Tiwari N., Sabbah H.N., Gupta R.C.Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart.