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PKC β Polyclonal Antibody, 100μg, (ATB-T3756)

PKC β Polyclonal Antibody, 100μg, (ATB-T3756)

Store / Antibodies and Immunodetection Reagents / Primary Antibodies
$199.00
In stock
Product Details

Background: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description PKC β Polyclonal Antibody, 100μg, (ATB-T3756) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human PKC β around the non-phosphorylation site of S661. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Hyperglycaemia promotes human brain microvascular endothelial cell apoptosis via induction of protein kinase C-ßI and prooxidant enzyme NADPH oxidase. Shao B, et al. Redox Biol, 2014. PMID 24936444 Free PMC Article PKCβII acts downstream of chemoattractant receptors and mTORC2 to regulate cAMP production and myosin II activity in neutrophils. Liu L, et al. Mol Biol Cell, 2014 May. PMID 24600048 Free PMC Article Protein kinase C isoforms in atherosclerosis: pro- or anti-inflammatory? Fan HC, et al. Biochem Pharmacol, 2014 Mar 15. PMID 24440741 Genomewide RNAi screen identifies protein kinase Cb and new members of mitogen-activated protein kinase pathway as regulators of melanoma cell growth and metastasis. Schönherr M, et al. Pigment Cell Melanoma Res, 2014 May. PMID 24406113 PKC-β exacerbates in vitro brain barrier damage in hyperglycemic settings via regulation of RhoA/Rho-kinase/MLC2 pathway. Srivastava K, et al. J Cereb Blood Flow Metab, 2013 Dec. PMID 23963366 Free PMC Article

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PKC β Polyclonal Antibody, 100μg, (ATB-T3756)
Store / Antibodies and Immunodetection Reagents / Primary Antibodies
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