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OSR1 (Phospho-Thr185) Rabbit Polyclonal Antibody, 100 ug
Background: The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008]Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton.Product datasheet: Overview Product Description Oxidative-stress responsive 1 gene is located in the vicinity of three others genes - GOLGA4, ITGA9 and HYA22 on chromosome 3. These four genes are considered to be candidate tumor suppressors. Oxidative-stress responsive 1 protein has similarity to human Ste20/oxidant stress response kinase-1 and is thought to be involved in the response to oxidative stress Tested Applications WB,IHC Image Western blot analysis of extracts from HepG2 cells treated with serum using OSR1 (Phospho-Thr185) Antibody #11746.The lane on the right is treated with the antigen-specific peptide. Species Reactivities Human Immunogen Peptide sequence around phosphorylation site of threonine185(R-K-T(p)-F-V) derived from Human OSR1. Properties Storage Instructions Store at -20°C Clonality Polyclonal Antibody References: Crystal structure of domain-swapped STE20 OSR1 kinase domain. Lee SJ, et al. Protein Sci, 2009 Feb. PMID 19177573 Free PMC Article Structure of the OSR1 kinase, a hypertension drug target. Villa F, et al. Proteins, 2008 Dec. PMID 18831043 Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3. Tamari M, et al. J Hum Genet, 1999. PMID 10083736 Calcium-binding protein 39 facilitates molecular interaction between Ste20p proline alanine-rich kinase and oxidative stress response 1 monomers. Ponce-Coria J, et al. Am J Physiol Cell Physiol, 2012 Dec 1. PMID 23034389 Free PMC Article STK39 is an independent risk factor for male hypertension in Han Chinese. Chen LY, et al. Int J Cardiol, 2012 Jan 26. PMID 20889219 Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3. Tamari M., Daigo Y., Nakamura Y.J. Hum. Genet. 44:116-120(1999) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT ILE-304. Tissue: Skeletal muscleImported
Manually validated information which has been imported from another database.
More… Manual assertion inferred from database entries i EMBL:BAA75674.1
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