Myb (Phospho-Ser532) Rabbit Polyclonal Antibody, 100 ug

Background: This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.Product datasheet: Overview Product Description Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. Tested Applications IHC Species Reactivities Human Mouse Immunogen Peptide sequence around phosphorylation site of serine 532 (V-E-S(p)-P-T) derived from Human Myb. Properties Storage Instructions Store at -20°C Clonality Polyclonal Antibody References: A subset of prostatic basal cell carcinomas harbor the MYB rearrangement of adenoid cystic carcinoma. Bishop JA, et al. Hum Pathol, 2015 Aug. PMID 26089205 Detection of MYB Alterations and Other Immunohistochemical Markers in Primary Cutaneous Adenoid Cystic Carcinoma. North JP, et al. Am J Surg Pathol, 2015 Oct. PMID 26076064 MYB rearrangement and clinicopathologic characteristics in head and neck adenoid cystic carcinoma. Rettig EM, et al. Laryngoscope, 2015 Sep. PMID 25963073 Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer. Mtatiro SN, et al. BMC Med Genet, 2015 Feb 10. PMID 25928412 Free PMC Article A unifying gene signature for adenoid cystic cancer identifies parallel MYB-dependent and MYB-independent therapeutic targets. Gao R, et al. Oncotarget, 2014 Dec 30. PMID 25587024 Free PMC Article Human c-myb protooncogene: nucleotide sequence of cDNA and organization of the genomic locus. Majello B., Kenyon L.C., Dalla-Favera R.Proc. Natl. Acad. Sci. U.S.A. 83:9636-9640(1986) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Alternative splicing of the human c-myb gene. Westin E.H., Gorse K.M., Clarke M.F.Oncogene 5:1117-1124(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Genome annotation of a 1.5 Mb region of human chromosome 6q23 encompassing a quantitative trait locus for fetal hemoglobin expression in adults. Close J.P., Game L., Clark B., Bergounioux J., Gerovassili A., Thein S.L.BMC Genomics 5:33-33(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4). Characterization of the complete sequence structure of the human c-myb gene. Westin E.H., Gorse K.M.Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 3; 4; 5 AND 6). Tissue: Liver and Placenta. Gaillard C., Perbal B.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).