MEK5(phospho-Ser311/ Thr315) Rabbit Polyclonal Antibody, 100 ug

Background: kinase involved in signal transduction in the cell [RGD, Feb 2006] Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis (By similarity). Product datasheet: Overview Product Description Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appear to play a critical role in protecting cells from stress-induced apopotosis, neuronal survival and cardiac development and angiogenesis. Tested Applications WB Image Western blot analysis of extracts from Rat and Mouse brain tissue using MEK5(phospho-Ser311/ Thr315) Antibody #11559. Species Reactivities Human Mouse Rat Immunogen Peptide sequence around phosphorylation site of Serine 311 and threonine 315 (V-N-S(p)I-A-K-T(p)-Y-V) derived from Rat MEK5. Properties Storage Instructions Store at -20C Clonality Polyclonal Antibody References: Modulation of F-actin rearrangement by the cyclic AMP/cAMP-dependent protein kinase (PKA) pathway is mediated by MAPK-activated protein kinase 5 and requires PKA-induced nuclear export of MK5. Gerits N, et al. J Biol Chem, 2007 Dec 21. PMID 17947239 Mitogen-activated protein kinase activated protein kinase 2 (MK2) participates in p38 MAPK regulated control of oligodendrocyte differentiation. Haines JD, et al. Glia, 2010 Aug 15. PMID 20607863 MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion. Mehta PB, et al. Oncogene, 2003 Mar 6. PMID 12618764 Isolation of MEK5 and differential expression of alternatively spliced forms. English JM, et al. J Biol Chem, 1995 Dec 1. PMID 7499418 Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen-activated protein kinase signaling cascades. Stankiewicz TR, et al. J Biol Chem, 2015 Apr 10. PMID 25666619 Isolation of MEK5 and differential expression of alternatively spliced forms. English J.M., Vanderbilt C.A., Xu S., Marcus S., Cobb M.H. J. Biol. Chem. 270:28897-28902(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA-1; ALPHA-2 AND BETA), FUNCTION, MUTAGENESIS. Strain: Sprague-Dawley. Tissue: Brain. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA-1). Tissue: Lung.