Background: This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]Product datasheet: Overview Product Description L-Selectin Polyclonal Antibody, 100μg, (ATB-T15370) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human L-Selectin. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: L-selectin ligands expression in human fallopian tube epithelia of tubal pregnancies. Li S, et al. Biol Reprod, 2014 Jun. PMID 24829027 Plasma and serum L-selectin and clinical and subclinical cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis (MESA). Berardi C, et al. Transl Res, 2014 Jun. PMID 24631064 Quantifying the biomechanics of conception: L-selectin-mediated blastocyst implantation mechanics with engineered "trophospheres". Yucha RW, et al. Tissue Eng Part A, 2014 Jan. PMID 23927766 Free PMC Article L-selectin is a possible biomarker for individual PML risk in natalizumab-treated MS patients. Schwab N, et al. Neurology, 2013 Sep 3. PMID 23925765 Age is an important determinant in humoral and T cell responses to immunization with hepatitis B surface antigen. Rosenberg C, et al. Hum Vaccin Immunother, 2013 Jul. PMID 23571167
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