JunD (Phospho-Ser255) Rabbit Polyclonal Antibody, 100 ug

Background: The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013] Transcription factor binding AP-1 sites. Product datasheet: Overview Product Description Binds an AP-1 site and upon cotransfection stimulates the activity of a promoter that bears an AP-1 site. Tested Applications WB IHC Image Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using JunD (Phospho-Ser255) Antibody #11028 (left) or the same antibody preincubated with blocking peptide (right). Western blot analysis of extracts from 293 cells using JunD (Phospho-Ser255) Antibody #11028 (Lane 2) and the same antibody preincubated with blocking peptide (Lane1). Species Reactivities Human Mouse Rat Immunogen Peptide sequence around phosphorylation site of serine 255 (G-E-S(p)-P-P) derived from Human JunD. Properties Storage Instructions Store at -20C Clonality Polyclonal Antibody References: Higher risk of death among MEN1 patients with mutations in the JunD interacting domain: a Groupe d'etude des Tumeurs Endocrines (GTE) cohort study. Thevenon J, et al. Hum Mol Genet, 2013 May 15. PMID 23376981 Human T-cell leukemia virus type 1 (HTLV-1) bZIP factor requires cellular transcription factor JunD to upregulate HTLV-1 antisense transcription from the 3' long terminal repeat. Gazon H, et al. J Virol, 2012 Sep. PMID 22696638 Free PMC Article JunD-mediated repression of GADD45 and regulates escape from cell death in prostate cancer. Zerbini LF, et al. Cell Cycle, 2011 Aug 1. PMID 21734453 Free PMC Article JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Caffarel MM, et al. Oncogene, 2008 Aug 28. PMID 18454173 JunD mediates androgen-induced oxidative stress in androgen dependent LNCaP human prostate cancer cells. Mehraein-Ghomi F, et al. Prostate, 2008 Jun 15. PMID 18386285 Structure and function of human jun-D. Berger I., Shaul Y. Oncogene 6:561-566(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. NIEHS SNPs program Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-20. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spleen. Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Isolation of human cDNA clones of jun-related genes, jun-B and jun-D. Nomura N., Ide M., Sasamoto S., Matsui M., Date T., Ishizaki R. Nucleic Acids Res. 18:3047-3048(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 45-347.