JunB (Phospho-Ser259) Rabbit Polyclonal Antibody, 100 ug

Background: Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'. Product datasheet: Overview Product Description Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'. Tested Applications WB IHC Image Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using JunB (Phospho-Ser259) Antibody #11027 (left) or the same antibody preincubated with blocking peptide (right). Western blot analysis of extracts from HT29 cells untreated or treated with EGF using JunB (Phospho-Ser259) Antibody #11027. Species Reactivities Human Mouse Rat Immunogen Peptide sequence around phosphorylation site of serine 259 (P-V-S(p)-P-I) derived from Human JunB. Properties Storage Instructions Store at -20C Clonality Polyclonal Antibody References: Mitogen-activated protein kinase signaling controls basal and oncostatin M-mediated JUNB gene expression. Hicks MJ, et al. Mol Cell Biochem, 2015 May. PMID 25662951 JUNB promotes the survival of Flavopiridol treated human breast cancer cells. Hicks M, et al. Biochem Biophys Res Commun, 2014 Jul 18. PMID 24858691 JunB mediates basal- and TGF1-induced smooth muscle cell contractility. Ramachandran A, et al. PLoS One, 2013. PMID 23308222 Free PMC Article Translational control of JunB, an AP-1 transcription factor, in activated human endothelial cells. Schmid DI, et al. J Cell Biochem, 2013 Jul. PMID 23297064 Free PMC Article Expression of junB is markedly stimulated by glycyrrhizin in a human hepatoma cell line. Koike K. Oncol Rep, 2011 Mar. PMID 21225234 jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun. Schuette J., Viallet J., Nau M., Segal S., Fedorko J., Minna J. Cell 59:987-997(1989) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Isolation of human cDNA clones of jun-related genes, jun-B and jun-D. Nomura N., Ide M., Sasamoto S., Matsui M., Date T., Ishizaki R. Nucleic Acids Res. 18:3047-3048(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci. Phinney D.G., Tseng S.W., Ryder K. Genomics 28:228-234(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta. NIEHS SNPs program Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-230. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.