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Gab1 (Phospho-Tyr627) Rabbit Polyclonal Antibody, 100 ug
Background: The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] Product datasheet: Overview Product Description The protein encoded by Gab1 is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Tested Applications WB IF Image Western blot analysis of extracts from 293 cells untreated or treated with EGF using Gab1 (Phospho-Tyr627) Antibody #11291. Immunofluorescence staining of methanol-fixed Hela cells using Gab1(Phospho-Tyr627) Antibody #11291. Species Reactivities Human Mouse Immunogen Peptide sequence around phosphorylation site of tyrosine 627 (V-E-Y(p)-L-D) derived from Human Gab1. Properties Storage Instructions Store at -20C Clonality Polyclonal Antibody References: Gab1 is essential for membrane translocation, activity and integrity of mTORCs after EGF stimulation in urothelial cell carcinoma. Chang CH, et al. Oncotarget, 2015 Jan 30. PMID 25596749 Free PMC Article Novel inhibitors induce large conformational changes of GAB1 pleckstrin homology domain and kill breast cancer cells. Chen L, et al. PLoS Comput Biol, 2015 Jan. PMID 25569504 Free PMC Article Characterization of GAB1 expression over the menstrual cycle in women with and without polycystic ovarian syndrome provides a new insight into its pathophysiology. Roemer KL, et al. J Clin Endocrinol Metab, 2014 Nov. PMID 25144631 Free PMC Article Key roles for GRB2-associated-binding protein 1, phosphatidylinositol-3-kinase, cyclooxygenase 2, prostaglandin E2 and transforming growth factor alpha in linoleic acid-induced upregulation of lung and breast cancer cell growth. Mouradian M, et al. Prostaglandins Leukot Essent Fatty Acids, 2014 Apr. PMID 24374147 Free PMC Article Down-regulation of Gab1 inhibits cell proliferation and migration in hilar cholangiocarcinoma. Sang H, et al. PLoS One, 2013. PMID 24312291 Free PMC Article
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IntelixBio has swiftly become a household name in the medical industry, primarily owing to its cutting-edge medical lab equipment. Our commitment to excellence resonates through every facet of our products, ensuring that laboratories worldwide receive top-tier solutions for their diagnostic needs. Our medical lab equipment is engineered with precision and innovation, embodying the pinnacle of technological advancement in the field. From state-of-the-art analyzers to automated specimen-handling systems, our extensive catalog caters to diverse laboratory requirements, fostering efficiency and accuracy in every diagnostic process. Laboratories entrust IntelixBio's medical lab equipment for its unwavering reliability, empowering healthcare professionals with the tools they need to deliver optimal patient care.
At IntelixBio, our dedication to advancing healthcare is exemplified through our unparalleled range of medical lab equipment. Each product is meticulously crafted to meet the exacting standards of modern laboratory environments, facilitating seamless integration and operation. Our commitment to quality permeates every aspect of our offerings, ensuring that laboratories can consistently rely on our medical lab equipment to deliver precise and dependable results. With a comprehensive selection that spans from basic laboratory essentials to sophisticated diagnostic instruments, IntelixBio remains the foremost choice for institutions seeking excellence in medical equipment solutions. Trust IntelixBio to elevate your laboratory capabilities with our innovative medical lab equipment, empowering you to drive progress in healthcare delivery.
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At IntelixBio LLC, we offer high-quality medical lab equipment. Our lab supplies include:
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