Background: The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Product datasheet: Overview Product Description GAP43 encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Tested Applications IF Image Immunofluorescence staining of methanol-fixed Hela cells using GAP43 (Phospho-Ser41) Antibody #11281. Species Reactivities Human Mouse Rat Immunogen Peptide sequence around phosphorylation site of Ser41 (Q-A-S(p)-F-R) derived from Human GAP43. Properties Storage Instructions Store at -20C Clonality Polyclonal Antibody References: Growth-associated protein 43 in differentiating peripheral nerve sheath tumors from other non-neural spindle cell neoplasms. Chen WS, et al. Mod Pathol, 2014 Feb. PMID 23887302 Growth-associated protein 43 expression in ganglionic and aganglionic colon. Grynspan D, et al. Pediatr Dev Pathol, 2012 Sep-Oct. PMID 23153097 Expression of growth-associated protein 43 in the skin nerve fibers of patients with type 2 diabetes mellitus. Bursova S, et al. J Neurol Sci, 2012 Apr 15. PMID 22209024 Genetic and functional analysis of the gene encoding GAP-43 in schizophrenia. Shen YC, et al. Schizophr Res, 2012 Feb. PMID 22138049 Cellular and molecular bases of neuroplasticity: brainstem effects after cochlear damage. Gil-Loyzaga P, et al. Acta Otolaryngol, 2010 Mar. PMID 19593683
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