Background: This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description Ferritin heavy chain Polyclonal Antibody, 100μg, (ATB-T1692) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human Ferritin heavy chain. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Coupling heme and iron metabolism via ferritin H chain. Gozzelino R, et al. Antioxid Redox Signal, 2014 Apr 10. PMID 24124891 Free PMC Article Elevated serum ferritin level is associated with the incident type 2 diabetes in healthy Korean men: a 4 year longitudinal study. Jung CH, et al. PLoS One, 2013. PMID 24098686 Free PMC Article Relationship of serum ferritin levels to sleep fragmentation and periodic limb movements of sleep on polysomnography in autism spectrum disorders. Youssef J, et al. Pediatr Neurol, 2013 Oct. PMID 24053984 Ferritin H is a novel marker of early erythroid precursors and macrophages. Wang W, et al. Histopathology, 2013 May. PMID 23611361 Diagnostic use of serum ferritin levels to differentiate infectious and noninfectious diseases in patients with fever of unknown origin. Kim SE, et al. Dis Markers, 2013. PMID 23324584 Free PMC Article
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