Background: Product datasheet: Overview Product Description Cdc25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. Tested Applications WB Image Western blot analysis of extracts from HT29 cells, treated with PMA or calf intestinal phosphatase (CIP), using Cdc25B (Phospho-Ser149) Antibody #11553. Western blot analysis of extracts from 3T3 cells untreated (lane 1) or treated with Hydroxyurea (lane 2) using Cdc25B (Phospho-Ser149) Antibody #11553. Species Reactivities Mouse Immunogen Peptide sequence around phosphorylation site of Serine 149 (F-R-S(p)-L-P) derived from Mouse Cdc25B. Properties Storage Instructions Store at -20C Clonality Polyclonal Antibody References: Cdc25B phosphatase participates in maintaining metaphase II arrest in mouse oocytes. Kang H, et al. Mol Cells, 2013 Jun. PMID 23661366 Free PMC Article [PKA-regulated phosphorylation status of S149 and S321 sites of CDC25B inhibits mitosis of fertilized mouse eggs]. Xiao JY, et al. Sheng Li Xue Bao, 2012 Feb 25. PMID 22348958 [Cdc25B overexpression reverses two-cell block in mouse embryos]. Cui C, et al. Zhongguo Ying Yong Sheng Li Xue Za Zhi, 2008 Feb. PMID 21141569 Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation. Lincoln AJ, et al. Nat Genet, 2002 Apr. PMID 11912493 Increased susceptibility to carcinogen-induced mammary tumors in MMTV-Cdc25B transgenic mice. Yao Y, et al. Oncogene, 1999 Sep 16. PMID 10498865 High-efficiency full-length cDNA cloning. Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6JImported
Information which has been imported from another database using automatic procedures.
More Automatic assertion inferred from database entries i EMBL:BAB23603.1
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