Calmodulin (Phospho-Thr79/Ser81) Rabbit Polyclonal Antibody, 100 ug

Background: Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca ²⁺ . Among the enzymes to be stimulated by the calmodulin-Ca ²⁺ complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.Product datasheet: Overview Product Description Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca2+. Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Tested Applications WB Image Western blot analysis of extracts from HeLa tissue using Calmodulin (Phospho-Thr79/Ser81) antibody #11978.The lane on the right is treated with the antigen-specific peptide. Species Reactivities Human Mouse Rat Immunogen Peptide sequence around phosphorylation site of threonine79/serine81(K-D-T(p)-D-S(p)-E-E) derived from Human Calmodulin . Properties Storage Instructions Store at -20°C Clonality Polyclonal Antibody References: CALM3 mutation associated with long QT syndrome. Reed GJ, et al. Heart Rhythm, 2015 Feb. PMID 25460178 A new polymorphism in human calmodulin III gene promoter is a potential modifier gene for familial hypertrophic cardiomyopathy. Friedrich FW, et al. Eur Heart J, 2009 Jul. PMID 19429631 Solution structure of Ca(2+)-calmodulin reveals flexible hand-like properties of its domains. Chou JJ, et al. Nat Struct Biol, 2001 Nov. PMID 11685248 Alpha-helix nucleation by a calcium-binding peptide loop. Siedlecka M, et al. Proc Natl Acad Sci U S A, 1999 Feb 2. PMID 9927666 Free PMC Article Complete amino acid sequence of human brain calmodulin. Sasagawa T, et al. Biochemistry, 1982 May 11. PMID 7093203 Isolation and nucleotide sequence of a cDNA encoding human calmodulin. Wawrzynczak E.J., Perham R.N.Biochem. Int. 9:177-185(1984) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Molecular analysis of human and rat calmodulin complementary DNA clones. Evidence for additional active genes in these species. Sengupta B., Friedberg F., Detera-Wadleigh S.D.J. Biol. Chem. 262:16663-16670(1987) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Multiple divergent mRNAs code for a single human calmodulin. Fischer R., Koller M., Flura M., Mathews S., Strehler-Page M.A., Krebs J., Penniston J.T., Carafoli E., Strehler E.E.J. Biol. Chem. 263:17055-17062(1988) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Structural organization of the human CaMIII calmodulin gene. Koller M., Schnyder B., Strehler E.E.Biochim. Biophys. Acta 1087:180-189(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (CALM3). Tissue: Blood. Structure of the human CALM1 calmodulin gene and identification of two CALM1-related pseudogenes CALM1P1 and CALM1P2. Rhyner J.A., Ottiger M., Wicki R., Greenwood T.M., Strehler E.E.Eur. J. Biochem. 225:71-82(1994) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (CALM1). Tissue: Blood.