CD19 (Phospho-Tyr531) Rabbit Polyclonal Antibody, 100 ug

Background: Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008] Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Product datasheet: Overview Product Description Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions. Tested Applications WB Image Western blot analysis of extracts from COS7 cells treated with Serum using Phospho-CD19 (Tyr531) antibody #11910.The lane on the right is treated with the antigen-specific peptide. Species Reactivities Human Mouse Rat Immunogen Peptide sequence around phosphorylation site of tyrosine 531 (D-S-Y(p)-E-N) derived from Human CD19. Properties Storage Instructions Store at -20C Clonality Polyclonal Antibody References: Manufacture of T cells using the Sleeping Beauty system to enforce expression of a CD19-specific chimeric antigen receptor. Singh H, et al. Cancer Gene Ther, 2015 Mar. PMID 25591810 A unique population of IgG-expressing plasma cells lacking CD19 is enriched in human bone marrow. Mei HE, et al. Blood, 2015 Mar 12. PMID 25573986 Misdiagnosed CD19 deficiency leads to severe lung disease. Skendros P, et al. Pediatr Allergy Immunol, 2014 Oct. PMID 24684239 Contribution of cerebrospinal fluid sCD19 levels to the detection of CNS lymphoma and its impact on disease outcome. Muiz C, et al. Blood, 2014 Mar 20. PMID 24501214 Is CD19 an immunological diagnostic marker for acute appendicitis? Mosayebi G, et al. Iran J Immunol, 2013 Dec. PMID 24375063 CD19, the earliest differentiation antigen of the B cell lineage, bears three extracellular immunoglobulin-like domains and an Epstein-Barr virus-related cytoplasmic tail. Stamenkovic I., Seed B. J. Exp. Med. 168:1205-1210(1988) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS VAL-174 AND HIS-514. Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily. Tedder T.F., Isaacs C.M. J. Immunol. 143:712-717(1989) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS VAL-174 AND HIS-514. Tissue: Tonsil. The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP. Kozmik Z., Wang S., Doerfler P., Adams B., Busslinger M. Mol. Cell. Biol. 12:2662-2672(1992) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-174. Structure of the genes encoding the CD19 antigen of human and mouse B lymphocytes. Zhou L.J., Ord D.C., Omori S.A., Tedder T.F. Immunogenetics 35:102-111(1992) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-174. Tissue: Blood. Polymorphisms of human CD19 gene: possible association with susceptibility to systemic lupus erythematosus in Japanese. Kuroki K., Tsuchiya N., Tsao B.P., Grossman J.M., Fukazawa T., Hagiwara K., Kano H., Takazoe M., Iwata T., Hashimoto H., Tokunaga K. Genes Immun. 3:S21-S30(2002) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-174.