BAD(Phospho-Ser155) Rabbit Polyclonal Antibody, 100 ug

Background: Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. Product datasheet: Overview Product Description Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. Tested Applications WB IHC Image Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using BAD (phospho- Ser155) antibody (#11069). Western blot analysis of extracts from 293 cells using BAD (phospho-Ser155) antibody (#11069). Species Reactivities Human Mouse Rat Immunogen Peptide sequence around phosphorylation site of serine 155(R-M-S(p)-D-E) derived from Human BAD. Properties Storage Instructions Store at -20C Clonality Polyclonal Antibody References: Fasting mediated increase in p-BAD(ser155) and p-AKT(ser473) in the prefrontal cortex of mice. Pitchaimani V, et al. Neurosci Lett, 2014 Sep 5. PMID 25043191 Behavioral stress accelerates prostate cancer development in mice. Hassan S, et al. J Clin Invest, 2013 Feb. PMID 23348742 Free PMC Article BAD modulates counterregulatory responses to hypoglycemia and protective glucoprivic feeding. Osundiji MA, et al. PLoS One, 2011. PMID 22162752 Free PMC Article A BAD link to mitochondrial cell death in the cochlea of mice with noise-induced hearing loss. Vicente-Torres MA, et al. J Neurosci Res, 2006 Jun. PMID 16521126 Free PMC Article BAD Ser128 is not phosphorylated by c-Jun NH2-terminal kinase for promoting apoptosis. Zhang J, et al. Cancer Res, 2005 Sep 15. PMID 16166315 Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Yang E., Zha J., Jockel J., Boise L.H., Thompson C.B., Korsmeyer S.J. Cell 80:285-291(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain and Thymus. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: NMRI. Tissue: Mammary gland. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Del Peso L., Gonzalez-Garcia M., Page C., Herrera R., Nunez G. Science 278:687-689(1997) [PubMed] [Europe PMC] Cited for: PHOSPHORYLATION AT SER-112 AND SER-136, MUTAGENESIS OF SER-112 AND SER-136. Rsk1 mediates a MEK-MAP kinase cell survival signal. Shimamura A., Ballif B.A., Richards S.A., Blenis J. Curr. Biol. 10:127-135(2000) [PubMed] [Europe PMC] Cited for: PHOSPHORYLATION AT SER-112 AND SER-136. 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Datta S.R., Katsov A., Hu L., Petros A., Fesik S.W., Yaffe M.B., Greenberg M.E. Mol. Cell 6:41-51(2000) [PubMed] [Europe PMC] Cited for: MUTAGENESIS OF SERINE RESIDUES.