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Anti SMAD4(D351H) Mouse Monoclonal Antibody, 100 ul (26418)

Anti SMAD4(D351H) Mouse Monoclonal Antibody, 100 ul (26418)

Store / Antibodies and Immunodetection Reagents / Primary Antibodies / Antibodies for Biomarkers
$495.00
In stock
Product Details

SMAD4(D351H) [26418] [100] Catalog Number: 26418 Gene Symbol: SMAD4, DPC4, JIP, MADH4, MYHRS Description: Anti SMAD4(D351H) Mouse Monoclonal Antibody Background: SMAD4 family member 4, also known as SMAD4, is a protein that in human is encoded by the SMAD4 gene. It is often found mutated in many cancers. It acts as a tumor suppressor that functions in the regulation of the TGF-? signal transduction pathway, which negatively regulates growth of epithelial cells and the extracellular matrix (ECM). SMAD4 alterations have been found in multiploid colorectal cancer and pancreatic carcinoma. It is found inactivated in at least 50% of pancreatic cancers. It is also found mutated in the autosomal dominantdisease juvenile polyposis syndrome (JPS). Immunogen: A synthetic peptide from the internal region of SMAD4 which includes the mutation of D351H, human origin. Applications: ELISA, WB, IHC Recommended Dilutions: ELISA: 1:1000-1:2000 WB: 1:500-1:1000 IHC: 1:50-1:100 Concentration: 1 mg/ml Host: Mouse Format: Liquid Clonality: Monoclonal Isotype: Purity: Purified from ascites Storage buffer: Preservative:no Constituents:PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol Species Reactivity: Recognizes D351H mutant, but not wild-type SMAD4 of vertebrates. Storage Conditions: Store at -20C. Avoid freeze / thaw cycles Download Datasheet: Western blot: Western blot analysis of recombinant SMAD4(D351H) and wildtype proteins. Purified His-tagged SMAD4(D351H) protein (lane1) and corresponding wild-type protein (1-552aa, 65kd) (lane2) were blotted with anti SMAD4(D351H) monoclonal antibody (Cat. #26418). Immunofluorescence: Immunofluorescence of cells expressing SMAD4 proteins with anti SMAD4(D351H) antibody. HEK293T cells were transfected with pCDNA3-GFP-SMAD4(D351H) plasmid , pCDNA3-GFP-SMAD4 (WT) plasmid or pCDNA3-GFP-SMAD4 (D351N) plasmid, then fixed and stained with anti-SMAD4(D351H) monoclonal antibody (Cat. #26418).

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Anti SMAD4(D351H) Mouse Monoclonal Antibody, 100 ul (26418)
Store / Antibodies and Immunodetection Reagents / Primary Antibodies / Antibodies for Biomarkers
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