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AKAP 13 Polyclonal Antibody, 100μg, (ATB-T0161)
Background: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. [provided by RefSeq, Jul 2012]Product datasheet: Overview Product Description AKAP 13 Polyclonal Antibody, 100μg, (ATB-T0161) Image Species Reactivities Human Immunogen Synthesized peptide derived from the Internal region of human AKAP 13. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Structural insights into the activation of the RhoA GTPase by the lymphoid blast crisis (Lbc) oncoprotein. Lenoir M, et al. J Biol Chem, 2014 Aug 22. PMID 24993829 Free PMC Article A regulatory SNP in AKAP13 is associated with blood pressure in Koreans. Hong KW, et al. J Hum Genet, 2011 Mar. PMID 21228793 AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade. Smith FD, et al. Nat Cell Biol, 2010 Dec. PMID 21102438 Free PMC Article Resonance assignments of the human AKAP13-PH domain and stabilizing DH helix. Sugawara M, et al. Biomol NMR Assign, 2009 Dec. PMID 19888694 The mRNA and protein expression of A-kinase anchor proteins 13 in human colorectal cancer. Hu JK, et al. Clin Exp Med, 2010 Mar. PMID 19779964
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IntelixBio has swiftly become a household name in the medical industry, primarily owing to its cutting-edge medical lab equipment. Our commitment to excellence resonates through every facet of our products, ensuring that laboratories worldwide receive top-tier solutions for their diagnostic needs. Our medical lab equipment is engineered with precision and innovation, embodying the pinnacle of technological advancement in the field. From state-of-the-art analyzers to automated specimen-handling systems, our extensive catalog caters to diverse laboratory requirements, fostering efficiency and accuracy in every diagnostic process. Laboratories entrust IntelixBio's medical lab equipment for its unwavering reliability, empowering healthcare professionals with the tools they need to deliver optimal patient care.
At IntelixBio, our dedication to advancing healthcare is exemplified through our unparalleled range of medical lab equipment. Each product is meticulously crafted to meet the exacting standards of modern laboratory environments, facilitating seamless integration and operation. Our commitment to quality permeates every aspect of our offerings, ensuring that laboratories can consistently rely on our medical lab equipment to deliver precise and dependable results. With a comprehensive selection that spans from basic laboratory essentials to sophisticated diagnostic instruments, IntelixBio remains the foremost choice for institutions seeking excellence in medical equipment solutions. Trust IntelixBio to elevate your laboratory capabilities with our innovative medical lab equipment, empowering you to drive progress in healthcare delivery.
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At IntelixBio LLC, we offer high-quality medical lab equipment. Our lab supplies include:
- Protective gear
- Antibody immunodetection supplies
- Bioreagents
- Lab Supplies
- Immunohistochemistry Tools
- Instruments and Equipment
- PPE
- Sample preparation supplies
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